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Rapid depletion of endogenous UA reserves during severe ischemia leads to the failure of the natural antioxidant defense system, triggering the need for urgent exogenous UA supplementation for cerebral protection during acute stroke [150]

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Ethics approval and consent to participate The medical ethics committee of the Maastricht University Medical Center+, the Netherlands approved the TearAD study (identifier: NL73600.068.20/METC 20033), and all participants provided written informed consent

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